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Microenvironmental Determinants of Pancreatic Cancer ...

2020-7-28 · Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment (TME) that dynamically evolves during tumor progression. The TME consists of different non-neoplastic cells such as cancer-associated fibroblasts, immune cells, endothelial cells, and …

Lilly | Eli Lilly and Company

Lilly unites caring with discovery to create medicines that make life better for people around the world.

Faculty Profile

Almyroudis NG, Fabian J, Hahn T, Segal BH, Wetzler M, McCarthy PL. (2009) Late infectious complications after cord blood stem cell transplantation. Eur J Clin Microbiol Infect Dis (Nov), 28(11): 1405-1408. Almyroudis NG, Segal BH. (2009) Prevention and treatment of invasive fungal diseases in neutropenic patients.

LSI Pub Corner | Life Sciences Institute

The carbohydrate-insulin model: a physiological perspective on the obesity pandemic. Am J Clin Nutr. 2021 Sep 13:nqab270. doi: 10.1093/ajcn/nqab270. Epub ahead of print. PMID: 34515299. https://pubmed.ncbi m.nih.gov/34515299/ 6. Durrer C, McKelvey S, Singer J, Batterham AM, Johnson JD, Gudmundson K, Wortman J, Little JP. A randomized ...

Microanatomy of the Human Atherosclerotic Plaque by …

Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, et al.. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic …

JCI

2019-3-12 · The equilibrium of signaling through activating and inhibitory receptors dictates whether a given NK cell will execute cellular cytotoxicity. In this issue of the JCI, Kamiya et al. describe a novel approach to efficiently inhibiting surface …

Publications | Medical Scientist Training Program ...

E. Aranda-Michel et al., "Miniaturized Robotic End-Effector With Piezoelectric Actuation and Fiber Optic Sensing for Minimally Invasive Cardiac Procedures," in IEEE ...

College of Biological Sciences

2021-7-6 · Profile Introduction. Dr. Bers'' heart research lab is an international group, using multiple state-of-the-art techniques to understand how normal and diseased heart cells function from the molecular detail to the whole animal level.There are typically 3-4 PhD students, 5-10 postdocs or senior researchers, as well as 2-3 technicians and several undergraduates.

Microanatomy of the Human Atherosclerotic Plaque by …

2021-12-3 · Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, et al.. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in …

JCI

2013-6-24 · Reverse transcription was performed with 0.3 μg of total RNA from each animal to produce cDNA in a 10-μl reaction with 200 units of SuperScript III Reverse Transcriptase (Invitrogen) and 500-ng oligo(dT)15 primers. Reverse transcriptase reactions were carried out at 25°C for 10 minutes, then 50 minutes at 42°C, and 15 minutes at 70°C.

Krzysztof Palczewski | UCI Profiles

2019-1-21 · Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem. 2004 Nov 26; 279 (48):50230-42. Moise AR, Kuksa V, Imanishi Y, Palczewski K. PMID: 15358783. Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma.

The sociability spectrum: evidence from reciprocal genetic ...

Sociability entails some of the most complex behaviors processed by the central nervous system. It includes the detection, integration, and interpretation of social cues and elaboration of context-specific responses that are quintessentially species-specific. There is an ever-growing accumulation of molecular associations to autism spectrum disorders (ASD), from causative …

Chimeric STAR receptors using TCR machinery mediate …

Unlike CAR-T cells, T cell receptor (TCR)–engineered T (TCR-T) cells recognize intracellular tumor antigens presented by major histocompatibility complex (MHC) molecules and engage CD3 signaling machinery, driving effective clearance of solid tumors (17–19).TCRαβ heterodimers lacks their own signaling domain and interact with CD3εγ, εδ, and ζζ subunits, which contain …

Frontiers | IFN-I Mediates Lupus Nephritis From the ...

Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) and a major risk factor for morbidity and mortality. The abundant cell-free nucleic (DNA/RNA) in SLE patients, especially dsDNA, is a key substance in the pathogenesis of SLE and LN. The deposition of DNA/RNA-immune complexes (DNA/RNA-ICs) in the glomerulus causes a series …

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JCI

Extracellular superoxide dismutase (EC-SOD, or SOD3) is the major extracellular antioxidant enzyme in the lung. To study the biologic role of EC-SOD in hyperoxic-induced pulmonary disease, we created transgenic (Tg) mice that specifically target overexpression of human EC-SOD (hEC-SOD) to alveolar type II and nonciliated bronchial epithelial cells.

Tumor-infiltrating natural killer cells

2021-1-1 · Introduction. Natural killer (NK) cells are cytotoxic innate immune cells of lymphoid origin that were first described in 1973 as "null" killer cells after the discovery that a non-T non-B lymphocyte subset could efficiently kill antibody-coated cells ().Two years later, the ability of NK cells to kill various types of tumor cells was reported, and the term "natural" killer cell was ...

IFNγ induces epigenetic programming of human T-bethi B ...

2019-5-15 · Recent studies from our group (Stone et al., 2019) revealed that differentiation of mouse B cells activated in the presence of IFNγ-producing T cells was dependent on B cell intrinsic expression of the IFNγR and the IFNγ-induced transcription factor (TF), T-bet.This result fit well with data from our group (Figure 1—figure supplement 1) and others (Rubtsova et al., …

Menopause Transition and Cardiovascular Disease Risk ...

2020-11-30 · Dis Model Mech. 2015; 8:1037–1046. doi: 10.1242/dmm.019950 Crossref Medline Google Scholar; 119. Veronese N, Notarnicola M, Osella AR, Cisternino AM, Reddavide R, Inguaggiato R, Guerra V, Rotolo O, Zinzi I, Chiloiro M, et al.. Menopause does not affect fatty liver severity in women: a population study in a Mediterranean area.

Chimeric antigen receptor

2021-7-15 · Chang YH, Connolly J, Shimasaki N, Mimura K, Kono K, Campana D. A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells. Cancer Res. 2013;73 ...

Robert J Coffey''s Profile

The Coffey lab seeks a comprehensive understanding of the role of EGF receptor (EGFR) and its ligands in epithelial cell growth, differentiation and neoplasia. In vitro, we study spatial compartmentalization of key components of the EGFR axis in the context of polarized epithelial cells. For example, two critical EGFR ligands, TGF-alpha and ...

Frontiers | Mitochondria as Key Players in the ...

2021-4-29 · Mitochondria are major energy-producing organelles that have central roles in cellular metabolism. They also act as important signalling hubs, and their dynamic regulation in response to stress signals helps to dictate the stress response of the cell. Rheumatoid arthritis is an inflammatory and autoimmune disease with high prevalence and complex aetiology.

Mammalian MAPK Signal Transduction Pathways Activated …

2020-6-13 · The mammalian stress-activated families of mitogen-activated protein kinases (MAPKs) were first elucidated in 1994, and by 2001, substantial progress had been made in identifying the architecture of the pathways upstream of these kinases as well as in cataloguing candidate substrates. This information remains largely sound. Nevertheless, an informed …

JCI

2016-11-21 · IL-6 is a major proinflammatory cytokine secreted during tissue damage. To our surprise, pericytes had significantly higher expression of Il6 compared with endothelial and epithelial cells and even macrophages in mouse kidneys following unilateral ischemia-reperfusion injury (IRI), which is a good model for human acute kidney injury . Together ...

Blocking expression of inhibitory receptor NKG2A …

2019-4-15 · Chang YH, Connolly J, Shimasaki N, Mimura K, Kono K, Campana D. A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells. Cancer Res. 2013; 73 (6):1777–1786. doi: 10.1158/0008-5472.CAN-12-3558. [Google Scholar]

Frontiers | Interleukin-22 Deficiency Contributes to ...

2021-10-25 · Mucosal tissue forms the first line of defense against pathogenic microorganisms. Cellular damage in the mucosal epithelium may induce the interleukin (IL)-22-related activation of many immune cells, which are essential for maintaining the mucosal epithelial barrier. A previous study on mucosal immunity elucidated that mammalian IL-22 contributes to mucus and …

Transcriptional and epigenetic regulation of macrophages ...

2019-10-2 · Transcriptional regulation. Transcriptional and phenotypic diversity is regulated on multiple interconnected levels through i.a. transcription factor and co-factor binding, the epigenetic landscape, long-range interactions, DNA methylation, RNA editing, and long non-coding RNAs.

Anti-VEGF Treatment Enhances CD8+ T-cell Antitumor ...

2020-6-1 · Antiangiogenic therapies that target the VEGF pathway have been used clinically to combat cancer for over a decade. Beyond having a direct impact on blood vessel development and tumor perfusion, accumulating evidence indicates that these agents also affect antitumor immune responses. Numerous clinical trials combining antiangiogenic drugs with …

Second-Generation Antidiabetic Sulfonylureas Inhibit ...

2020-1-27 · Using this model, our laboratory, along with others, has made significant progress in understanding the sequence of the events that contribute to the immunopathology. As C. albicans is polymorphic, it can switch between yeast and hyphal forms—a key virulence attribute for this fungal opportunist ( 8 ).

Menopause Transition and Cardiovascular Disease Risk ...

2020-11-30 · CVD and Menopause. Women develop coronary heart disease (CHD) several years later than men, with a notable increase in CHD risk during midlife, 4 a period coincident with the menopause transition (MT). This observation led to the hypothesis that the MT contributes to the increase in this risk. 4 Over the past 20 years, longitudinal studies of women transitioning …

PRL3-zumab, a first-in-class humanized antibody for …

2016-6-16 · Briefly, 96-well plates coated overnight with GST-PRL-1 (20 ng), GST-PRL-2 (20 ng), or GST-PRL-3 (1 ng) were blocked with 3% bovine serum albumin in PBS-0.05% Tween-20 prior to incubation with 200 ng PRL3-zumab for 2 hours at 37°C. After extensive washing, HRP-conjugated anti-mouse antibody (Pierce) was added for 1 hour at 37°C.

COVID-19 and the Heart and Vasculature | Arteriosclerosis ...

2020-7-20 · An outbreak of the novel severe acute respiratory syndrome (SARS) coronavirus-2 causing coronavirus disease 2019 (COVID-19) originally emerged from Wuhan, Hubei province in China, in December 2019. 1 On March 11, 2020, COVID-19 was declared a pandemic by the World Health Organization, and by July 30, 2020, the virus had infected over 17 million people …

Second-Generation Antidiabetic Sulfonylureas Inhibit ...

2020-1-27 · INTRODUCTION. Vulvovaginal candidiasis (VVC) is a common mucosal infection in immunocompetent women, overwhelmingly caused by the opportunistic fungus Candida albicans ().VVC is the most prevalent human candidal infection, affecting ~75% of the population at least once in their lifetime ().Moreover, 5 to 8% of all women suffer from recurrent infections …

JCI

The animal model of MS, experimental autoimmune encephalomyelitis (EAE), is a T cell–mediated autoimmune disease that can be induced by subcutaneous injection of peptides derived from myelin components such as myelin basic protein (MBP) (4 – 6), proteolipid protein (PLP) (7, 8), or myelin oligodendrocyte glycoprotein (MOG) .

Chimeric antigen receptor-engineered natural killer cells ...

2020-12-7 · Natural killer (NK) cells are a critical component of the innate immune system. Chimeric antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding antigens, creating major opportunities in the fight against cancer. CAR NK cells have the potential for use as universal CAR cells without the need for human leukocyte antigen matching or prior …